サンマルコクリニック 武蔵小杉の内分泌･糖尿病内科

若林一二, 南　史朗. 中枢神経とソマトスタチン. 最新医学 40: 926-931, 1985

周東祐仁, 若林一二, 亀谷　純, 杉原　仁, 南　史朗.　TSH不適合症候群の1家系. ホルモンと臨床 1: 136-140, 1992

南　史朗. 成長ホルモンの中枢性自己分泌調節機構. 日本医科大学雑誌　65: 409-412, 1998

南　史朗. 成長ホルモンのすべて—GH分泌調節機構「視床下部下垂体系に体するGH/IGF-1の作用と機序」. 内分泌・糖尿病科15 Suppl. 1, p. 84-90, 2002

南　史朗, 中田朋子. タンパク・遺伝子からみた分子病—新しく解明されたメカニズム−「成長ホルモン受容体(GHR)」. 生体の科学56: 428-429, 2005

南　史朗. GH/IGF-Iの分泌調節と経年変化.「成人成長ホルモン分泌不全症の臨床」千原和夫, 寺本明, 藤枝憲二編 メディカルレビュー社, p. 35-47, 2006

南　史朗. 糖尿病緊急症（糖尿病性昏睡および低血糖発作）.「内科エマージェンシー：病態生理の理解と診療の基本」救急医学2009年9月臨時増刊号33巻10号, 黒川顕編, へるす出版, ｐ1410-1414, 2009

南　史朗. 下垂体ホルモンの分泌機構‐GH系. 「下垂体腫瘍のすべて」, 寺本　明, 長村義之編, 医学書院, p16-26, 2009

南　史朗, 八木　孝.　下垂体疾患「ACTH単独欠損症」. 診断と治療 100巻7号別冊：1135-1141, 2012

安島弘美、中村　隆、南　史朗.　ジャイロセンサを用いた圧脈波センサ開発と食後血糖値測定技術の研究 Development of pressure-pulse-sensor using a gyro sensor for postprandial blood glucose level estimation. 日本機械学会論文集　87 (No. 901) 2021. DOI：https://doi.org/10.1299/transjsme.21-00076

Fujita Y, Harada H, Takeuchi T, Sato H, Minami S. Enhancement of EEG spikes and hyperpolarizations of pyramidal cells in the kindled hippocampus of the rabbit. Japanese J Physiology 33: 227-238, 1983

Fujita Y, Sato H, Takeuchi T, Minami S. Median raphe- and contralateral hippocampus-elicited EEG spikes which correspond to hyperpolarizations of pyramidal cells in the kindled hippocampus of the rabbit. Brain Research 278: 313-317, 1983

Minami S. Stimulation of the raphe nuclei produces EEG spikes in the hippocampus of the normal rabbit. J Nippon Medical School 51: 557-567, 1984

Minami S, Wakabayashi I, Tonegawa Y, Sugihara H, Akira S. Production of antisera to growth hormone-releasing factor: usefulness in radioimmunoassay and passive immunization. Endocrinologica Japonica 32: 907-916, 1985

Wakabayashi I, Hatano H, Minami S, Tonegawa Y, Akira S, Sugihara H, Ling N. Effects of neonatal administration of monosodium glutamate on plasma growth hormone (GH) response to GH-releasing factor in adult male and female rats. Brain Research 372: 361-365, 1986

Fujita Y, Harada H, Kitamura T, Minami S, Sato T. Dendritic activities of spinal motoneurones in pigs and rabbits enhanced through chronic stimulation of a dorsal root. J Physiology (London) 383: 171-190, 1987

Motoyama A, Wakabayashi I, Minami S, Sugihara H, Takahashi F, Akira S, Ling N. A radioimmunoassay for human pro-luteinizing hormone-releasing factor [pro-LRF(14-69)OH]. Endocrinologica Japonica 34: 133-137, 1987

Akira S, Wakabayashi I, Sugihara H, Minami S, Takahashi F, Motoyama A. Effect of testosterone on growth hormone secretion in female rats during a continuous infusion of growth hormone releasing factor. Neuroendocrinology 47: 116-124, 1988

Sugihara H, Wakabayashi I, Minami S, Takahashi F, Shibasaki T, Ling N. Effect of a-methyl-r-tyrosine and an antiserum to rat growth hormone (GH)-releasing factor (GRF) on plasma GH secretory profile during a continuous infusion of human GRF in rats. Brain Research 475: 128-133, 1988

Sugihara H, Minami S, Wakabayashi I. Post-somatostatin rebound secretion of growth hormone is dependent on growth hormone-releasing factor in unrestrained female rats. J Endocrinology 122: 583-591, 1989

Minami S, Wakabayashi I, Sugihara H, Kamegai J, Hasegawa O, Kitamura T, Yamada J. Effect of intermittent infusions of somatostatin on growth hormone secretion in unrestrained male rats with hypothalamic deafferentation. Brain Research 509: 293-298, 1990

Minami S, Frautschy SA, Plotsky PM, Sutton SW, Sarkar DK. Facilitatory role of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing hormone-releasing hormone. Neuroendocrinology 52: 112-115, 1990

Sarkar DK, Minami S. Effect of acute ethanol on beta-endorphin secretion from rat fetal hypothalamic neurons in primary cultures. Life Science 47: 31-36, 1990

Okada K, Wakabayashi I, Sugihara H, Minami S, Kitamura T, Yamada J. Electrical stimulation of hypothalamic periventricular nucleus is followed by a large rebound secretion of growth hormone in unanesthetized rats. Neuroendocrinology 53: 306-312, 1991

Kamegai J, Wakabayashi I, Sugihara H, Minami S, Kitamura T, Yamada J. Growth hormone secretion in stalk-sectioned rats. Acta Endocrinologica (Copenh) 124: 700-706, 1991

Wakabayashi I, Inokuchi K, Hasegawa O, Sugihara H, Minami S. Expression of growth hormone (GH)-releasing factor gene in GH-producing pituitary adenoma. J Clinic Endocrinol Metab 74: 357-361, 1992

Hasegawa O, Sugihara H, Minami S, Wakabayashi I. Masculinization of growth hormone (GH) secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin and GH-releasing hormone mRNA levels in ovariectomized adult rats. Peptides 13: 475-481, 1992

Shuto Y, Wakabayashi I, Amuro N, Minami S, Okazaki T. A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-α associated with a family with generalized resistance to thyroid hormone. J Clinic Endocrinol Metab 75: 213-217, 1992

Minami S, Kamegai J, Sugihara H, Hasegawa O, Wakabayashi I. Systemic administration of recombinant human growth hormone induces expression of the c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats. Endocrinology 131: 247-253, 1992

Sarkar DK, Kim KH, Minami S. Transforming growth factor-β1 messenger RNA and protein expression in the pituitary gland: its action on prolactin secretion and lactotropic growth. Molecular Endocrinology 6: 1825-1833, 1992

Minami S, Sarkar DK. Central administration of neuropeptide Y induces precocious puberty in female rats. Neuroendocrinology 56: 930-934, 1992

Sugihara H, Minami S, Okada K, Kamegai J, Hasegawa O, Wakabayashi I. Somatostatin reduces transcription of the growth hormone gene in rats. Endocrinology 132: 1225-1229, 1993

Kamegai J, Minami S, Sugihara H, Wakabayashi I. Barrel rotation evoked by intracerebroventricular injection of somatostatin and arginine-vasopressin is accompanied by the induction of c-fos gene expression in the granular cells of rat cerebellum. Molecular Brain Research 18: 115-120, 1993

Okada K, Sugihara H, Minami S, Wakabayashi I. Effect of parenteral administration of selected nutrients and central injection of γ-globulin from antiserum to neuropeptide Y on growth hormone secretory pattern in food-deprived rats. Neuroendocrinology 57: 678-686, 1993

Minami S, Kamegai J, Hasegawa O, Sugihara H, Okada K, Wakabayashi I. Expression of growth hormone receptor gene in rat hypothalamus. J Neuroendocrinol 5: 691-696, 1993

Hasegawa O, Minami S, Sugihara H, Wakabayashi I. Developmental expression of the growth hormone receptor gene in the rat hypothalamus. Developmental Brain Research 74: 287-290, 1993

Mori T, Inoue S, Egawa M, Takamura Y, Minami S, Wakabayashi I. Impaired growth hormone secretion in VMH lesioned rats. International Journal of Obesity 17: 349-353, 1993

Okada K, Suzuki N, Sugihara H, Minami S, Wakabayashi I. Restoration of growth hormone secretion in prolonged food-deprived rats depends on the level of nutritional intake and dietary protein. Neuroendocrinology 59: 380-386, 1994

Sawada H, Sugihara H, Onose H, Minami S, Shibasaki T, Wakabayashi I. Effect of D-Ala-D-Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats. Regulatory Peptides 53: 195-201, 1994

Kamegai J, Minami S, Sugihara H, Higuchi H, Wakabayashi I. Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats. Endocrinology 135: 2765-2771, 1994

Sarkar DK, Minami S. Diurnal variation in luteinizing hormone-releasing hormone and beta-endorphin release in pituitary portal plasma during the rat estrous cycle. Biology of Reproduction 53: 38-45, 1995

Suzuki N, Okada K, Sugihara H, Minami S, Wakabayashi I. Caloric intake stimulates growth hormone secretion in food-deprived rats with anterolateral deafferentation of the medial basal hypothalamus or administered antiserum to somatostatin. J Neuroendocrinol 7: 483-490, 1995

Minami S, Kamegai J, Sugihara H, Suzuki N, Higuchi H, Wakabayashi I. Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide Y neurons in the rat hypothalamus. Molecular Brain Research 33: 305-310, 1995

Okada K, Suzuki N, Sugihara H, Minami S, Wakabayashi I. Effects of hyper- and hypoglycemia on blood growth hormone level in free-feeding rats with anterolateral deafferentation of the medial basal hypothalamus. Brain Research 699: 33-41, 1995

Kamegai J, Minami S, Sugihara H, Hasegawa O, Higuchi H, Wakabayashi I. Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats. Endocrinology 137:2100-2112, 1996

Minami S, Sugihara H, Sato J, Tatsukuchi A, Sugisaki Y, Sasano H, Wakabayashi I. ACTH independent Cushing's syndrome occurring in siblings [Case report] . Clinical Endocrinology 44: 483-488, 1996

Kamegai J, Hasegawa O, Minami S, Sugihara H, Wakabayashi I. The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus. Molecular Brain Research 39: 153-159, 1996

Okada K, Ishii S, Minami S, Sugihara H, Shibasaki T, Wakabayashi I. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology 137: 5155-5158, 1996

Suzuki N, Okada K, Minami S, Wakabayashi I. Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus. Regulatory Peptides 65: 145-151, 1996

Sugihara H, Emoto N, Shibasaki T, Minami S, Wakabayashi I. Increased pituitary growth hormone-releasing factor (GRF) receptor messenger ribonucleic acid expression in food-deprived rats. Brain Research 742: 355-358, 1996

Minami S, Suzuki N, Sugihara H, Tamura H, Emoto N, Wakabayashi I. Microinjection of rat GH but not human IGF-I into a defined area of the hypothalamus inhibits endogenous GH secretion in rats. J Endocrinol, 153: 283-290, 1997

Tamura H, Sugihara H, Minami S, Emoto N, Shibasaki T, Shuto Y, Shimizu K, Gomi Y, Sasano H, Wakabayashi I. Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features [Case report]. Internal Medicine, 36: 804-809, 1997

Minami S, Sarkar DK. Transforming growth factor b-1 inhibits prolactin secretion and lactotropic cell proliferation in the pituitary of estrogen-treated Fischer 344 rats. Neurochem Int 30: 499-506, 1998

Minami S, Kamegai J, Sugihara H, Suzuki N, Wakabayashi I. Growth hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide Y neurons in the arcuate nucleus and somatostatin neurons in the periventricular nucleus. Endocrine J 45: S19-S26, 1998

Emoto N, Onose H, Sugihara H, Minami S, Shimizu K, Wakabayashi I. Fibroblast growth factor-2 free form from extracellular matrix is increased in papillary thyroid carcinomas and graves' thyroids. Thyroid 8: 491-497, 1998

Emoto N, Onose H, Yamada H, Minami S, Tushima T, Wakabayashi I. Growth factors increase pericellular proteoglycans independently of their mitogenic effects on A10 rat vascular smooth muscle cells. Int J Biochem Cell Biol 30: 47-54, 1998

Minami S, Nakata T, Tokita R, Onodera H, Imaki J. Cellular localization of prolactin-releasing peptide messenger RNA in the rat brain. Neuroscience Lett 266: 73-75, 1999

Tokita R, Nakata T, Katsumata H, Konishi S, Onodera H, Imaki J, Minami S. Prolactin secretion in response to prolactin-releasing peptide (PrRP) and the expression of the PrRP gene in the medulla oblongata are estrogen dependent in rats. Neurosci Lett 276: 103-106, 1999

Sugihara H, Emoto N, Tamura H, Kamegai J, Shibasaki T, Minami S, Wakabayashi I. Effect of insulin-like growth factor-I on growth hormone-releasing factor receptor expression in primary rat anterior pituitary cell culture. Neurosci Lett 276: 87-90, 1999

Yokota T, Nakata T, Minami S, Inazawa J, Emi M. Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. J Hum Genet 45: 5-11, 2000

Tamura H, Sugihara H, Kamegai J, Minami S, Wakabayashi I. Masculinizing effect of dihydrotestosterone on growth hormone secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats. J Neuroendocrinol 12: 369-375, 2000

Chikada N, Imaki T, Harada S, Nakajima K, Yoshimoto T, Naruse M, Demura H, Minami S, Takano K. Distribution of c-fos mRNA in the brain following intracerebroventricular injection of nitric oxide (NO)-releasing compound: possible role of NO in central cardiovascular regulation. J Neuroendocrinol 12: 1112-1123, 2000

Imaki T, Katsumata H, Miyata M, Naruse M, Imaki J, Minami S. Expression of corticotropin-releasing factor (CRF), urocortin, and CRF type 1 receptors in hypothalamic-hypophyseal systems under osmotic stimulation. J Neuroendocrinol 13: 328-338, 2001

Imaki T, Katsumata H, Miyata M, Naruse M, Imaki J, Minami S. Expression of corticotropin-releasing hormone type 1 receptor in paraventricular nucleus after acute stress. Neuroendocrinology 73: 293-301, 2001

Ogata K, An E, Shioi Y, Nakamura K, Luo S, Yokose N, Minami S, Dan K. Association between natural killer cell activity and infection in immunologically normal elderly people. Clinical and Experimental Immunology 124: 392-397, 2001

Nakata T, Yokota T, Emi M, Minami S. Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes, Chromosomes & Cancer 35: 30-37, 2002

Tokita R, Kasagi Y, Nakata T, Sakae K, Imaki T, Minami S. Microinjection of dihydrotestosterone into the medial preoptic area produces male-like pattern of growth hormone secretion in ovariectomized female rats. Neuroendocrinology 75: 384-391, 2002

Konishi S, Kasagi Y, Katsumata H, Minami S, Imaki T. Regulation of corticotropin-releasinga factor (CRF) type-1 receptor gene expression by CRF in the hypothalamus. Endocrine J 50: 21-36, 2003

Imaki T, Katsumata H, Konishi S, Kasagi Y, Minami S. Corticotropin-releasing factor type-1 receptor mRNA is not induced in mouse hypothalamus by either stress or osmotic stimulation. J Neuroenodocrinol 15: 916-924, 2003

Kasagi Y, Tokita R, Nakata T, Imaki T, Minami S. Human growth hormone induces SOCS3 and CIS mRNA increase in the hypothalamic neurons of hypophysectomized rats. Endocrine J 51: 145-154, 2004

Toyoshima Y, Hakuno F, Kato H, Minami S, Takahashi SI. Hepatic insulin signals are enhanced in rats fed on low-protein diets, a model of IGF resistance. Growth Horm IGF Res 18: S23, 2008

Suzuki N, Tsumoto K, Hajicek N, Daigo K, Tokiga R, Minami S, Kodama T, Hamakubo T, Kozasa T. Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearraingements in the interface. J Biol Chem 284: 5000-9, 2009

Osaka M, Tokita R, Minami S. Volley-like male GH secretion indicates existence of an intrinsic 1-h oscillator in the hypothalamus. Applied Mathematical and Computational Sciences 1, 225-242, 2010

Toyoshima Y, Tokita R, Ohne Y, Hakuno F, Noguchi T, Minami S, Kato H, Takahashi S. Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver. J Mol Endocrinol 45: 329-340, 2010

Cha P-C, Mushiroda T, Takahashi A, Kubo M, Minami S, Kamatani N, Nakamura Y. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. Human Molecular Genetics 19: 4735-4744, 2010

Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase-binding protein, PITKAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Mol Endocrinol 26: 1043-55, Epub, 2012

Fukushima T, Nakamura Y, Yamanaka D, Shibano T, Chida K, Minami S, Asano T, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation. J Biol Chem 287: 29713-21, 2012

Okamoto Y, Ishii So, Croce K, Katsumata H, Fukushima M, Kihara S, Libby P, Minami S. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques. Atherosclerosis 226: 373-377, 2013

Ishii S, Okamoto Y, Katsumata H, Minami S. Sunitinib, a small-molecule receptor tyrosine kinase inhibitor, suppresses neointimal hyperplasia in balloon-injured rat carotid artery. J Cardiovascular Pharmacology and Therapeutics 18: 359-266, 2013

Kaneko M, Hakuno F, Kamei H, Yamanaka D, Chida K, Minami S, Coe IR, Takahashi S. Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters. Biochem Biophys Res Com 443: 505-510, 2014

Toyoshima Y, Tokita R, Taguchi Y, Akiyama-Akanishi N, Takenaka A, Kato H, Chida K, Hakuno F, Minami S, Takahashi S. Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats. Endocrine J 61: 499-512, 2014

Fukushima M, Okamoto Y, Katsumata H, Ishikawa M, Ishii S, Okamoto M, Minami S. Growth hormone ameliorate adipose dysfunction during oxidative stress and inflammation and improves glucose tolerance in obese mice. Hormone and Metabolic Research 46: 656-662, 2014

Orikasa C, Nagaoka K, Katsumata H, Minami S, Kondo Y, Sakuma Y. Social isolation prompts maternal behavior in sexually naïve male ddN mice. Physiology & Behavior 151: 9-15, 2015

Yamanaka D, Akama T, Chida K, Minami S, Ito K, Hakuno F, Takahashi S. Phosphatidylinositol 3-kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro and enhances endocytosis in HEK293 cells. Front Endocrinol (Lausanne) 7: Article 89, 2016

Zhou H, Mori S, Ishizaki T, Takahashi A, Matsuda K, Koretsune Y, Minami S, Higashiyama M, Imai S, Yoshimori K, Doita M, Yamada A, Nagayama S, Kaneko K, Asai S, Shiono M, Kubo M, Ito H. Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis. Bone Reports 5: 158-172, 2016

Orikasa C, Kondo Y, Katsumata H, Terada M, Akimoto T, Sakuma Y, Minami S. Vomeronasal signal deficiency enhances parental behavior in socially isolated male mice. Physiology & behavior168: 98-102, 2017

Taguchi Y, Toyoshima Y, Tokita R, Kato H, Takahashi S, Minami S. Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling. Biochem Biophys Res Com 490: 800-805, 2017

Minami S, et al. Biobank Japan project: Epidemiological study. Journal of Epidemiology 27-3S: S1-S106, 2017

Mushiroda T, Minami S, Kubo M, et al. Association of HLA-A*31:01 screening with the incidence of carbamazepine-induced cutaneous adverse reactions in a Japanese population. JAMA Nuerology 75(7): 842-849, 2018

Yano H, Sakai M, Yagi T, Naganuma T, Matsukawa T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M. PHD3 regulates glucose metabolism by suppressing stress-induced signaling and optimizing gluconeogenesis and insulin signaling in hepatocytes. Scientific Reports 8: 14290, 2018

Yagi T, Toyoshima Y, Tokita R, Taguchi Y, Okamoto Y, Takahashi S, Kato H, Mianmi S. Low-protein diet enhances adiponectin secretion in rats. Bioscience, Biotechnology, and Biochemistry 83: 1774-1781, 2019

Nakata T, Hirano Y, Katsumata H, Tokita R, Yagi T, Toyoshima Y, Minami S. Growth hormone activates X-box binding protein 1 in a sexually dimorphic manner through the extracellular signal-regulated protein kinase and CCAAT/enhancer-binding protein β pathway in rat liver. Endocrine J 67: 185-200, 2020

Toyoshima Y, Yoshizawa F, Tokita R, Taguchi Y, Takahashi S, Kato H, Minami S. A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation. Am J Physiol Endocrinol Metab. 318: E636-E645, 2020

Nakata T, Toyoshima Y, Yagi T, Katsumata H, Tokita R, Minami S. Growth hormone increases regulator of calcineurin 1-4 (Rcan 1-4) mRNA through c-JUN in rat liver. PLOS One: Published: June 26, 2020: https://doi.org/10.1371/journal.pone.0235270

Ishigaki K, Minami S, Kamatani Y et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature Genetics 52: 669–679, 2020

Toyoshima Y, Nakamura K, Tokita R, Teramoto N, Sugihara H, Kato H, Yamanouchi K, and Minami S. Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. J Biol Chem 295(33):11914-11927, 2020

Orikasa C, Kato Y, Katsumata H, Inutsuka A, Yamanaka A, Onaka T, Minami S. Involvement of MCH-oxytocin neural relay within the hypothalamus in murine nursing behavior. Scientific Reports 11: 3348, 2021

Sakaue S, Minami S, Okada Y, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nature Genetics 53:　1415-1424, 2021

Namkoong H, Yagi T, Minami S, et al. DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature 609: 754-760, 2022

Matsukawa T, Yagi T, Minami S, et al. Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models. J Clin Invest 2023: https://insight.jci.org/articles/view/161282

（最近5年間の発表論文）

Muroya K, Kawai M, Yamagishi H, Endo T, Pietropoli A, Ferran JM,Horikawa R. Endocr J. 2025 Nov 22. doi: 10.1507/endocrj.EJ25-0116. Long-term effectiveness and safety of daily growth hormone therapy in Japanese children with Noonan syndrome: a post-marketing surveillance study.
Horikawa R, Tanaka T, Hasegawa Y, Yorifuji T, Ng D, Rosenfeld RG, Hoshino Y, Okayama A, Ebata N, Hosoi M, Nakamuta S, Gomez R, Pastrak A, Castellanos O.Endocr J. 2025 Oct 31. doi: 10.1507/endocrj.EJ24-0625. Efficacy and safety of once-weekly somatrogon following up to 4 years of treatment in Japanese children with growth hormone deficiency: results from an open-label extension of a phase 3 study.
Fujita S, Kabashima S, Yanagi K, Toyokuni K, Yoshida K, Miyaji Y, Takada S, Motomura K, Tamari M, Nakazaki H, Hayashi Y, Nagano N, Uchiyama T, Oishi K, Yokoya S, Yoshioka T, Tanase-Nakao K, Yamamoto-Hanada K, Fukuie T,Horikawa R, Saito H, Matsubara Y, Ohya Y, Kaname T, Matsumoto K, Morita H. J Allergy Clin Immunol. 2025 Oct 14:S0091-6749(25)00976-5. doi: 10.1016/j.jaci.2025.09.012. JAK1 gain-of-function variant causes alopecia areata, atopic dermatitis, and autoimmune thyroid disease.
Katoh-Fukui Y, Saito D, Narumi H, Hattori A, Igarashi M, Uehara E, Shima H, Kanno J, Hasegawa Y,Horikawa R, Nagasaki K, Fukami M.Hum Genome Var. 2025 Sep 8;12(1):18. doi: 10.1038/s41439-025-00322-2.PMID: 40916030  DHX37 variants in patients with 46,XY disorders or differences of sex development.
Tseretopoulou X, Chen J, Lucas-Herald A, Charmandari E, Choi JH, Dou X, Hamza R, Harvey J, Hoffman AR,Horikawa R, Johannsson G, de Lima Jorge AA, Miller BS, Pietropoli A, Sävendahl L, Vitali D, Wajnrajch M, Chen SC, Gong C, Ahmed SF.J Clin Endocrinol Metab. 2025 Sep 5:dgaf500. doi: 10.1210/clinem/dgaf500. Online ahead of print.PMID: 40911547 Trends In Reported Outcomes For Growth Hormone Therapy In Children With Growth Hormone Deficiency. 
Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS,Horikawa R, Tanaka T, Dörr HG, Polak M, Grimberg A.Ther Adv Endocrinol Metab. 2025 Aug 17;16:20420188251345556. doi: 10.1177/20420188251345556. A database study of the safety and effectiveness of daily growth hormone in treating more than 80,000 children with growth disorders worldwide: a plain language summary of publication.
Kawai M, Murakami N,Horikawa R, Muroya K, Fujisawa Y, Hoshino Y, Okayama A, Sato T, Ebata N, Ogata T.Endocr J. 2025 Aug 1;72(8):925-935. doi: 10.1507/endocrj.EJ24-0659. Epub 2025 May 28.PMID: 40436776  Improvement in body composition of Japanese participants with Prader-Willi syndrome following somatropin treatment: an open-label, multi cohort Phase 3 study.
Miller BS, Blair JC, Rasmussen MH, Frystyk J, Lemminger AK, Maniatis A, Mori J, Böttcher V, Kim HS, Polak M, Horikawa R. Eur J Endocrinol. 2025 Apr 30;192(5):651-661. doi: 10.1093/ejendo/lvaf096.PMID: 40400262 Efficacy, safety, and insulin-like growth factor I of weekly somapacitan in children with growth hormone deficiency: 3-year results from REAL4.
Hokken-Koelega ACS, van der Steen M, Boguszewski MCS, Cianfarani S, Dahlgren J, Horikawa R, Mericq V, Rapaport R, Alherbish A, Braslavsky D, Charmandari E, Chernausek SD, Cutfield WS, Dauber A, Deeb A, Goedegebuure WJ, Hofman PL, Isganatis E, Jorge AA, Kanaka-Gantenbein C, Kashimada K, Khadilkar V, Luo XP, Mathai S, Nakano Y, Yau M. International Consensus Guideline on Small for Gestational Age (SGA): Etiology and Management from Infancy to Early Adulthood. Endocr Rev. 2023 Jan 13:bnad002. Epub ahead of print.
Aoki S, Hashimoto K, Ogawa K, Horikawa R, Sago H. Developmental outcomes in Japanese preschool-age children conceived through assisted reproductive technology. J Obstet Gynaecol Res. 2022;48(11):2847-2852.
Maghnie M, Ranke MB, Geffner ME, Vlachopapadopoulou E, Ibáñez L, Carlsson M, Cutfield W, Rooman R, Gomez R, Wajnrajch MP, Linglart A, Stawerska R, Clayton PE, Darendeliler F, Hokken-Koelega ACS, Horikawa R, Tanaka T, Dörr HG, Albertsson-Wikland K, Polak M, Grimberg A. Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort. J Clin Endocrinol Metab. 2022;107(12):3287-3301.
Miller BS, Blair JC, Rasmussen MH, Maniatis A, Kildemoes RJ, Mori J, Polak M, Bang RB, Böttcher V, Stagi S, Horikawa R. Weekly Somapacitan is Effective and Well Tolerated in Children With GH Deficiency: The Randomized Phase 3 REAL4 Trial. J Clin Endocrinol Metab. 2022 107(12):3378-3388.
Morisaki N, Obara T, Piedvache A, Kobayashi S, Miyashita C, Nishimura T, Ishikuro M, Sata F, Horikawa R, Mori C, Metoki H, Tsuchiya KJ, Kuriyama S, Kishi R. Association between smoking and hypertension in pregnancy among Japanese women: a meta-analysis of birth cohort studies in the Japan Birth Cohort Consortium (JBiCC) and JECS. J Epidemiol. 2022 Aug 6.Epub ahead of print.
Ota T, Katsumata N, Naiki Y, Horikawa R. Novel non-stop variant of the NR0B1 gene in two siblings with adrenal hypoplasia congenita. J Pediatr Endocrinol Metab. 2022;35(9):1189-1193.
Horikawa R, Tanaka T, Hasegawa Y, Yorifuji T, Ng D, Rosenfeld RG, Hoshino Y, Okayama A, Shima D, Gomez R, Pastrak A, Castellanos O. Efficacy and Safety of Once-Weekly Somatrogon Compared with Once-Daily Somatropin (Genotropin®) in Japanese Children with Pediatric Growth Hormone Deficiency: Results from a Randomized Phase 3 Study. Horm Res Paediatr. 2022;95(3):275-285.
Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L, Touraine P, van Santen HM, Johannsson G. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus
statement. Eur J Endocrinol. 2022;186(6):P35-P52.

Sävendahl L, Battelino T, Højby Rasmussen M, Brod M, Saenger P, Horikawa R. Effective GH Replacement With Once-weekly Somapacitan vs Daily GH in Children with GHD: 3-year Results From REAL 3. J Clin Endocrinol Metab. 2022;107(5):1357-1367.
Naiki Y, Miyado M, Shindo M, Horikawa R, Hasegawa Y, Katsumata N, Takada S, Akutsu H, Onodera M, Fukami M. Adeno-Associated Virus-Mediated Gene Therapy for Patients' Fibroblasts, Induced Pluripotent Stem Cells, and a Mouse Model of Congenital Adrenal Hyperplasia. Hum Gene Ther. 2022;33(15-16):801-809.
Saito J, Kawasaki H, Adachi N, Sasaki A, Yakuwa N, Suzuki T, Sago H, Yamatani A, Horikawa R, Murashima A. Diazoxide during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk, and infant serum: a case report. Gynecol Endocrinol. 2022;38(6):528-530.
Jorge AAL, Edouard T, Maghnie M, Pietropoli A, Kelepouris N, Romano A, Zenker M, Horikawa R. Outcomes in growth hormone-treated Noonan syndrome children: impact of PTPN11 mutation status. Endocr Connect. 2022;11(4):e210615.
Kobayashi M, Ogawa K, Morisaki N, Tanaka H, Horikawa R, Urayama KY. Relationship between Maternal Mood Disorders and Dietary Intake of 3-Year-Olds. J Nutr Metab. 2021;2021:5597836.
Shimizu S, Sakamoto S, Fukuda A, Yanagi Y, Uchida H, Mimori K, Nakao T, Sun C, Horikawa R, Kasahara M. Surgical technique and the long-term outcomes of pediatric living donor domino liver transplantation from patients with maple syrup urine disease. Pediatr Transplant. 2022;26(2):e14174.
Kasahara M, Sakamoto S, Fukuda A, Horikawa R, Ito R, Uchida H, Yanagi Y, Shimizu S, Nakao T, Mimori K, Haga C, Schlegel A, Ohtake A, Shimura M, Fushimi T, Ichimoto K, Matsunaga A, Murayama K. Macroscopic Characteristics of the Native Liver in Children With MPV17-Related Mitochondrial DNA Depletion Syndrome: An Indication for Performing Liver Transplantation? Liver Transpl. 2022;28(3):497-500.
Yoshida T, Matsumoto K, Miyado M, Miyashiro Y, Sago H, Horikawa R, Fukami M. Quantification of androgens and their precursors in full-term human placenta. Eur J Endocrinol. 2022;185(5):K7-K11.
Shimizu S, Sakamoto S, Yamada M, Fukuda A, Yanagi Y, Uchida H, Mimori K, Shoji K, Funaki T, Miyairi I, Nakano N, Haga C, Yoshioka T, Imadome KI, Horikawa R, Kasahara M. Immunological features and complications in patients with glycogen storage disease 1b after living donor liver transplantation. Pediatr Transplant. 2021;25(8):e14104.
Uchida H, Sakamoto S, Shimizu S, Yanagi Y, Fukuda A, Horikawa R, Ito R, Matsunaga A, Murayama K, Kasahara M. Outcomes of liver transplantation for mitochondrial respiratory chain disorder in children. Pediatr Transplant. 2021 ;25(8):e14091.
Kido J, Matsumoto S, Häberle J, Inomata Y, Kasahara M, Sakamoto S, Horikawa R, Tanemura A, Okajima H, Suzuki T, Nakamura K. Role of liver transplantation in urea cycle disorders: Report from a nationwide study in Japan. J Inherit Metab Dis. 2021;44(6):1311-1322.
Shibata M, Ogawa K, Kanazawa S, Kawasaki M, Morisaki N, Mito A, Sago H, Horikawa R, Arata N. Association of maternal birth weight with the risk of low birth weight and small-for-gestational-age in offspring: A prospective single-center cohort study. PLoS One. 2021;16(5):e0251734.
Hanew K, Tanaka T, Horikawa R, Hasegawa T, Yokoya S. The current status of 492 adult women with Turner syndrome: a questionnaire survey by the Foundation for Growth Science. Endocr J. 2021;68(9):1081-1089. Kido J, Matsumoto S, Häberle J, Nakajima Y, Wada Y, Mochizuki N, Murayama K, Lee T, Mochizuki H, Watanabe Y, Horikawa R, Kasahara M, Nakamura K. Long-term outcome of urea cycle disorders: Report from a nationwide study in Japan. J Inherit Metab Dis. 2021;44(4):826-837.
Sakamoto A, Ogura M, Hattori A, Tada K, Horikawa R, Nakadate H, Matsumoto K, Nogami K, Ieko M, Ishiguro A. Lupus anticoagulant hypoprothrombinemia syndrome associated with bilateral adrenal haemorrhage in a child: early diagnosis and intervention. Thromb J. 2021;19(1):19.
Haraguchi H, Harada M, Kashimada K, Horikawa R, Sakakibara H, Shozu M, Fujii T, Osuga Y, Kugu K. National survey of primary amenorrhea and relevant conditions in Japan. J Obstet Gynaecol Res. 2021;47(2):774-777.
Horikawa R, Tanaka T, Nishinaga H, Nishiba Y, Yokoya S. The long-term safety and effectiveness of growth hormone treatment in Japanese children with short stature born small for gestational age. Clin Pediatr Endocrinol. 2020;29(4):159-171.
Igarashi M, Masunaga Y, Hasegawa Y, Kinjo K, Miyado M, Saitsu H, Kato-Fukui Y, Horikawa R, Okubo Y, Ogata T, Fukami M. Nonsense-associated altered splicing of MAP3K1 in two siblings with 46,XY disorders of sex development. Sci Rep. 2020;10(1):17375.
Saeki T, Takano E, Sunayama H, Kamon Y, Horikawa R, Kitayama Y, Takeuchi T. Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection. J Mater Chem B. 2020;8(35):7987-7993.
Ando E, Morisaki N, Asakura K, Ogawa K, Sasaki S, Horikawa R, Fujiwara T. Association between dietary intake and serum biomarkers of long-chain PUFA in Japanese preschool children. Public Health Nutr. 2020:1-11.
Miyoshi Y, Yorifuji T, Shimizu C, Nagasaki K, Kawai M, Ishiguro H, Okada S, Kanno J, Takubo N, Muroya K, Ito J, Horikawa R, Yokoyama S, Ozono K. A nationwide questionnaire survey targeting Japanese pediatric endocrinologists regarding transitional care in childhood, adolescent, and young adult cancer survivors. Clin Pediatr Endocrinol. 2020;29(2):55-62.
Horikawa R, Ogata T, Matsubara Y, Yokoya S, Ogawa Y, Nishijima K, Endo T, Ozono K. Long-term efficacy and safety of two doses of Norditropin® (somatropin) in Noonan syndrome: a 4-year randomized, double-blind, multicenter trial in Japanese patients. Endocr J. 2020;67(8):803-818.
Irie R, Nakazawa A, Sakamoto S, Takeda M, Yanagi Y, Shimizu S, Uchida H, Fukuda A, Horikawa R, Kasahara M. Etiology of liver dysfunction after liver transplantation in children with metabolic disorders. Hepatol Res. 2020;50(5):635-642.
Sävendahl L, Battelino T, Brod M, Højby Rasmussen M, Horikawa R, Juul RV, Saenger P; REAL 3 study group. Once-Weekly Somapacitan vs Daily GH in Children With GH Deficiency: Results From a Randomized Phase 2 Trial. J Clin Endocrinol Metab. 2020;105(4):e1847–61.
Shimizu S, Sakamoto S, Horikawa R, Fukuda A, Uchida H, Takeda M, Yanagi Y, Irie R, Yoshioka T, Kasahara M. Longterm Outcomes of Living Donor Liver Transplantation for Glycogen Storage Disease Type 1b. Liver Transpl. 2020;26(1):57-67.
Maeda Y, Ogawa K, Morisaki N, Tachibana Y, Horikawa R, Sago H. Association between perinatal anemia and postpartum depression: A prospective cohort study of Japanese women. Int J Gynaecol Obstet. 2020;148(1):48-52.
Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res
Paediatr. 2019;92(1):1-14.

Bangalore Krishna K, Fuqua JS, Rogol AD, Klein KO, Popovic J, Houk CP, Charmandari E, Lee PA, Freire AV, Ropelato MG, Yazid Jalaludin M, Mbogo J, Kanaka-Gantenbein C, Luo X, Eugster EA, Klein KO, Vogiatzi MG, Reifschneider K, Bamba V, Garcia Rudaz C, Kaplowitz P, Backeljauw P, Allen DB, Palmert MR, Harrington J, Guerra-Junior G, Stanley T, Torres Tamayo M, Miranda Lora AL, Bajpai A, Silverman LA, Miller BS, Dayal A, Horikawa R, Oberfield S, Rogol AD, Tajima T, Popovic J, Witchel SF, Rosenthal SM, Finlayson C, Hannema SE, Castilla-Peon MF, Mericq V, Medina Bravo PG. Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium. Horm Res Paediatr. 2019;91(6):357-372.
Ogushi K, Hattori A, Suzuki E, Shima H, Izawa M, Yagasaki H, Horikawa R, Uetake K, Umezawa A, Ishii T, Muroya K, Namba N, Tanaka T, Hirano Y, Yamamoto H, Soneda S, Matsubara K, Kagami M, Miyado M, Fukami M. DNA Methylation Status of SHOX-Flanking CpG Islands in Healthy Individuals and Short Stature Patients with Pseudoautosomal Copy Number Variations. Cytogenet Genome Res. 2019;158(2):56-62.
Hattori A, Okamura K, Terada Y, Tanaka R, Katoh-Fukui Y, Matsubara Y, Matsubara K, Kagami M, Horikawa R, Fukami M. Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells. BMC Med Genomics. 2019;12(1):77.
Yoshii K, Matsumoto H, Hirasawa K, Sakauchi M, Hara H, Ito S, Osawa M, Fukami M, Horikawa R, Nagata S. Microdeletion in Xq28 with a polymorphic inversion in a patient with FLNA-associated progressive lung disease. Respir Investig. 2019;57(4):395-398.
Numakura C, Tamiya G, Ueki M, Okada T, Maisawa SI, Kojima-Ishii K, Murakami J, Horikawa R, Tokuhara D, Ito K, Adachi M, Abiko T, Mitsui T, Hayasaka K. Growth impairment in individuals with citrin deficiency. J Inherit Metab Dis. 2019;42(3):501-508.
Suzuki E, Shima H, Kagami M, Soneda S, Tanaka T, Yatsuga S, Nishioka J, OtoY, Kamiya T, Naiki Y, Ogata T, Fujisawa Y, Nakamura A, Kawashima S, Morikawa S, Horikawa R, Sano S, Fukami M. (Epi)genetic defects of MKRN3 are rare in Asian patients with central precocious puberty. Hum Genome Var. 2019;6:7.
Kasahara M, Sakamoto S, Horikawa R, Fukuda A. Auxiliary Partial Orthotopic Liver Transplantation for Noncirrhotic Metabolic Liver Disease: Reigniting Interest in an Old but New Technique. Liver Transpl. 2019;25(1):12-13.

（その他の主要論文・国際ガイドラインなど）

Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and Insulin secretion in patients with acromegaly. Horikawa R, Takano K, Hizuka N,  Asakawa K, Shibasaki T,  Masuda A, Shizume K .  Endocrinol Japon 33(6) ：　743-749 (1986)
Developmental changes of IGF-I receptors in rat testis. Horikawa R, Asakawa K, Hizuka N, Takano K and Shizume K. Exp Clin Endocrinol (Life Sci Adv) 6(4) ：273-277 (1987)
Treatment of acromegaly with long acting somatostatin analogue SMS 201-995. Horikawa R, Takano K, Hizuka N, Asakawa K, Sukegawa I, Hirose N, Horiba N, Kasono K, Masuda A, Ohba Y, Nakagami Y, Tsushima T, Shizume K.  Endocrinol Japon 35(5) ：741-751 (1988 ) Growth hormone and insulin-like growth factor I stimulate Leydig cell steroidogenesis. Horikawa R, Asakawa K, Hizuka N, Takano K and Shizume K.  Eur J Pharmacol 166(1) ：87-94 (1989)
Hypothalamic-pituitary dysfunction in patients with CHARGE association. Horikawa R, Itoh J, Tanaka T, Tanae A and Hibi I.  Clin Pediatr Endocrinol 2(1) ：1-6 (1993)
Clinical significance of growth hormone-binding protein measurements in children. Horikawa R, Tanaka T, Katsumata N, Satoh M, Nagashima A, Watanabe T, Kokai Y, Tanae A, Hibi I.  Proc Soc Exp Biol Med 　206(3) ： 320-323 (1994)
Growth hormone-binding protein measurements in normal children and children with short stature using ligand-mediated immunofunctional assay.　Horikawa R, Tanaka T, Kokai Y, Katsumata N, Nagashima A, Satoh M, Tanae A and Hibi I. Clin Pediatr Endocrinol ： 335-43 (1994)
Growth hormone-releasing factor (GRF) regulates expression of its own receptor. Horikawa R, Hellmann P, Cella S V, Torsello A, Day R N, Muller E E, Thorner M O.  Endocrinology 137(6) ： 2642-2645 (1996)
The regulatory effect of growth hormone on growth hormone-binding protein in human serum. Horikawa R, Tanaka T, Katsumata N, Tanae A.  Endocr J.　45(Suppl) ：S113-S115 (1998)
Regulation of pituitary growth hormone-secretagogue and growth hormone-releasing hormone receptor RNA expression in young Dwarf rats. Horikawa R, Tachibana T, Katsumata N, Ishikawa H, Tanaka T.  Endocr J. 47 (Suppl) ： S53-S56 (2000).
Molecular cloning of ovine and bovine growth hormone-releasing hormone receptors: the ovine receptor is C-terminally truncated.  Horikawa R, Gaylinn BD, Lyons CE, Thorner MO.  142(6) ： 2660-2668 (2001)
Growth hormone treatment in short Japanese children born small for gestational age.　Horikawa R, Tanaka T.　 Horm Res 62 (suppl 3): 128-136 (2004) Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients.　Fukami M, Horikawa R, Nagai T, Tanaka T, Naiki Y, Sato N, Okuyama T, Nakai H, Soneda S, Tachibana K, Matsuo N, Sato S, Homma K, Nishimura G, Hasegawa T, Ogata T.　 J Clin Endocrinol Metab　90(1) : 414-426 (2005)
Horikawa R. [Endocrine disease: progress in diagnosis and treatment. Topics: I. Progress in diagnosis; 5. Gonad: clinical approach to disorder of sex development (DSD)]. Nihon Naika Gakkai Zasshi. 101(4):965-74.: 2012 　Japanese
Sugihara S, Ogata T, Kawamura T, Urakami T, Takemoto K, Kikuchi N, Takubo N, Tsubouchi K, Horikawa R, Kobayashi K, Kasahara Y, Kikuchi T, Koike A, Mochizuki T, Minamitani K, Takaya R, Mochizuki H, Nishii A, Yokota I, Kizaki Z, Mori T, Shimura N, Mukai T, Matsuura N, Fujisawa T, Ihara K, Kosaka K, Kizu R, Takahashi T, Matsuo S, Hanaki K, Igarashi Y, Sasaki G, Soneda S, Teno S, Kanzaki S, Saji H, Tokunaga K, Amemiya S; Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT). HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families. Pediatr Diabetes.13(1):33-44.:2012
Guidelines for diagnosis and treatment of 21-hydroxylase deficiency (2014 revision). Mass Screening Committee; Japanese Society for Pediatric Endocrinology; Japanese Society for Mass Screening, Ishii T, Anzo M, Adachi M, Onigata K, Kusuda S, Nagasaki K, Harada S, Horikawa R, Minagawa M, Minamitani K, Mizuno H, Yamakami Y, Fukushi M, Tajima T. Clin Pediatr Endocrinol. 2015 Jul;24(3):77-105.

Witchel SF, Oberfield S, Rosenfield RL, Codner E, Bonny A, Ibáñez L, Pena A, Horikawa R, Gomez-Lobo V, Joel D, Tfayli H, Arslanian S, Dabadghao P, Garcia Rudaz C, Lee PA. The Diagnosis of Polycystic Ovary Syndrome during Adolescence. Horm Res Paediatr. 2015 Apr 1.
Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. Eur J Endocrinol. 2016 Jun;174(6):C1-8. doi: 10.1530/EJE-16-0111.
Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care. Lee PA, Nordenström A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH 3rd, Mazur T, Meyer-Bahlburg HF, Mouriquand P, Quigley CA, Sandberg DE, Vilain E, Witchel S; Global DSD Update Consortium. Horm Res Paediatr. 2016;85(3):158-80. doi: 10.1159/000442975. Review. Erratum in: Horm Res Paediatr. 2016;85(3):180. Koopman, Peter [added].
The influence of a long-term growth hormone treatment on lipid and glucose metabolism: a randomized trial in short Japanese children born small for gestational age. Horikawa R, Tanaka T, Nishinaga H, Ogawa Y, Yokoya S. Int J Pediatr Endocrinol. 2016;2016:19.
Horikawa R, Tanaka T, Nishinaga H, Ogawa Y, Yokoya S Evaluation of growth hormone treatment efficacy in short Japanese children born small for gestational age: Five-year treatment outcome and impact on puberty. Clin Pediatr Endocrinol. 2017;26(2):63-72.

1．S Kagiyama, T Koga, S Kaseda, S Ishihara, N Kawazoe, S Sadoshima. Transient precordial ST elevation by a spasm of the conus artery during right coronary angiography. Int J Cardiol. 2007; 116: e57-e59.

2．Kagiyama S, Koga T, Kaseda S,Ishihara S, Kawazoe N, Sadoshima S, Matsumura K, Takata Y, Tsuchihashi T, Iida M. Correlation between increased urinary sodium excretion and decreased left ventricular diastolic function in patients with type 2 diabetes mellitus. Clin Cardiol. 2009 Oct; 32(10): 569-74.

3．石原嗣郎、古賀徳之、矢成亮介、的野る美、加世田繁、村上昇、藤島慎一郎、川副信行、佐渡島省三：好酸球増多症性心筋炎に巨大冠動脈血栓閉塞を来たした急性心筋梗塞症例．心臓41 suppl.3 2009

4．石原嗣郎，古賀徳之，加世田繁，村上昇，藤島慎一郎，川副信行，佐渡島省三：凝固能亢進が原因と考えられたbare metal stentに発症したlate thrombosisの1例．心臓42 suppl.2 2010

5．石原嗣郎，古賀徳之，入田英二，芳賀祥江，加世田繁，藤島慎一郎，石束隆男：高血圧患者におけるアリスキレン長期投与の中心血圧および血中アルドステロンに対する効果．血圧18 no.9 2011

6．Shiro Ishihara, Tokushi Koga, Shigeru Kaseda, Eiji Nyuta, Yoshie Haga, Shinichiro Fujishima, Takao Ishitsuka, Seizo Sadoshima. Effects of intravenous nicorandil on the mid-term prognosis of patients with acute heart failure syndrome. Circ J 2012; 76: 1169-1176.

7．Fujishima S, Murakami N, Haga Y, Nyuta E, Nakate Y,Ishihara S, Kaseda S, Koga T, Ishitsuka T. Low diastolic blood pressure was one of the independent predictors of ischemia-like findings of electrocardiogram in patients who underwent coronary angiography. J Cardiol. 2013 Oct; 62(4): 230-5.

8．Ravi Shah, Shiro Ishihara, et al. For the GREAT Network. Body mass index and mortality in acutely decompensated heart failure across the world: A global obesity paradox. J Am Coll Cardiol 2014 Mar 4; 63(8): 778-85.

9．Vodovar N, Séronde MF, Laribi S, Gayat E, Lassus J, Boukef R, Nouira S, Manivet P, Samuel JL, Logeart D, Ishihara S, Cohen Solal A, Januzzi JL Jr, Richards AM, Launay JM, Mebazaa A; on behalf of the GREAT Network. Post-translational modifications enhance NT-proBNP and BNP production in acute decompensated heart failure. Eur Heart J.2014 Dec 21; 35(48): 3434-41.

10．A Cohen-Solal, S Laribi, S Ishihara, G Vergaro, M Baudet, D Logeart, A Mebazaa, E Gayat, N Vodovar, DA Pascual-Figal, M-F Seronde. Prognostic markers of acute decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic Arch Cardiovasc Dis.2015 Jan; 108(1): 64-74.

11．Teixeira A, Parenica J, Park JJ,Ishihara S, AlHabib KF, Laribi S, Maggioni A, Miró Ò, Sato N, Kajimoto K, Cohen-Solal A, Fairman E,Lassus J, Mueller C, Peacock WF, Januzzi JL Jr, Choi DJ, Plaisance P , Spinar J, Mebazaa A, Gayat E; GREAT (Global Research on Acute Conditions Team) Network. Clinical presentation and outcome by age categories in acute heart failure: results from an international observational cohort. Eur J Heart Fail. 2015 Sep 30. doi: 10.1002/ejhf.330.

12．E Ganovska, M Arrigo, K Helanova, S Littnerova, M Sadoune, P Kubena, S Ishihara, et al. on behalf of the GREAT Network. Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: A prospective observational cohort study. Int J Cardiol. 2016; 215: 527-531

13．Ishihara S, Gayat E, Sato N, Arrigo M, Laribi S, Legrand M, Placido R, Manivet P, Cohen-Solal A, Abraham WT, Jessup M, Mebazaa A. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure. Clin Res Cardiol. 2016 Jun 17.

14．Arrigo M, Gayat E, Parenica J, Ishihara S, Zhang J, Choi DJ, Park JJ, Alhabib KF, Sato N, Miro O, Maggioni AP, Zhang Y, Spinar J, Cohen-Solal A, Iwashyna TJ, Mebazaa A; GREAT Network. Precipitating factors and 90-day outcome of acute heart failure: a report from the intercontinental GREAT registry. Eur J Heart Fail. 2016 Oct 28. doi: 10.1002/ejhf.682.

15．Javed Butler, Shiro Ishihara, et al. Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations. Circ Heart Fail. 2017; Apr;10(4). pii: e003800. doi:10.1161/CIRCHEARTFAILURE.116.003800.

16．Gayat E, Arrigo M, Littnerova S, Sato N, Parenica J, Ishihara S, Spinar J, Müller C, Harjola VP, Lassus J, Miró Ò, Maggioni AP, AlHabib KF, Choi DJ, Park JJ, Zhang Y, Zhang J, Januzzi JL Jr, Kajimoto K, Cohen-Solal A, Mebazaa A; GREAT Network. Heart failure oral therapies at discharge are associated with better outcome in acute heart failure: a propensity-score matched study. Eur J Heart Fail.2017 Aug 28. doi: 10.1002/ejhf.932.

17．Takagi K, Sato N, Ishihara S, Sone M, Tokuyama H, Nakama K, Omote T, Kikuchi A, Ishikawa M, Amitani K, Takahashi N, Maruyama Y, Imura H, Shimizu W. Effects of tolvaptan on urine output in hospitalized heart failure patients with hypoalbuminemia or proteinuria. Heart Vessels. 2017 Oct 23. doi: 10.1007/s00380-017-1066-4.

18．Legrand M, Ishihara S, et al. GREAT (Global Research on Acute Conditions Team) Network and INI-CRCT (Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists) network. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. Clin Res Cardiol. 2017 Oct 28. doi: 10.1007/s00392-017-1173-3.

19．Akiyama E, Van Aelst LNL, Arrigo M, Lassus J, Miró Ò, Čelutkienė J, Choi DJ, Cohen-Solal A, IshiharaS, Kajimoto K, Laribi S, Maggioni AP, Motiejunaite J, Mueller C, Parenica J, Park JJ, Sato N, Spinar J, Zhang J, Zhang Y, Kimura K, Tamura K, Gayat E, Mebazaa A; GREAT (Global Research on Acute Conditions Team) Network. East Asia may have a better 1-year survival following an acute heart failure episode compared with Europe: results from an international observational cohort. Eur J Heart Fail. 2018 Jun;20(6): 1071-1075.

20．Arrigo M, IshiharaS, Feliot E, Rudiger A, Deye N, Cariou A, Guidet B, Jaber S, Leone M, Resche-Rigon M, Vieillard Baron A, Legrand M, Gayat E, Mebazaa A. New-onset atrial fibrillation in critically ill patients and its association with mortality: A report from the FROG-ICU study. Int J Cardiol. 2018 Sep 1; 266:95-99.

21．HD Dungen, Shiro Ishihara, et al. A new educational program in heart failure drug development: the Brescia international master program. J Cardiovasc Med (Hagerstown).2018 Aug; 19(8): 411-421.

22．T Javanainen, S Ishihara, E Gayat, B Charbit, R Jurkko, R Cinotti, A Mebazaa, and on behalf of the FROG-ICU investigators. Prolonged corrected QT interval is associated with short-term and long-term mortality in critically ill patients: results from the FROG-ICU study. Intensive Care Med.2019 May; 45(5): 746-748.

23．Matthieu Legrand, Shiro Ishihara, et al. One-Year Prognosis of Kidney Injury at Discharge From the ICU: A Multicenter Observational Study. Crit Care Med.2019 Dec; 47(12): e953-e961.

24．Hiroyuki Tsutsui, Shiro Ishihara, et al. On behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure -Digest Version-. Circ J.2019 Sep 25;83(10): 2084-2184.

25．K Takagi, S Ishihara, N Kenji, H Iha, N Kobayashi, Y Ito, T Nohara, S Ohkuma, T Mitsuishi, A Ishizuka, S Shigihara, M Sone, H Tokuyama, T Omote, A Kikuchi, S Nakamura, E Yamamoto, M Ishikawa, W Shimizu. Clinical significance of arterial stiffness as a factor for hospitalization of heart failure with preserved left ventricular ejection fraction: a retrospective matched case-control study. J Cardiol. 2020 Aug;76(2): 171-176.

26．Takagi K, Sato N, Ishihara S, Iha H, Kobayashi N, Ito Y, Nohara T, Ohkuma S, Mitsuishi T, Ishizuka A, Shigihara S, Sone M, Nakama K, Tokuyama H, Omote T, Kikuchi A, Nakamura S, Yamamoto E, Ishikawa M, Amitani K, Takahashi N, Maruyama Y, Imura H, Shimizu W. Differences in pharmacological property between combined therapy of the vasopressin V2-receptor antagonist tolvaptan plus furosemide and monotherapy of furosemide in patients with hospitalized heart failure. J Cardiol. 2020 Nov;76(5): 499-505.

27．A Kimmoun, K Takagi, E Gall, S Ishihara, P Hammoum, NE Bèze, A Bourgeois, G Chassard, H Pegorer-Sfes, E Gayat, AC. Solal, A Hollinger, T Merkling, A Mebazaa, METAHF Team. Temporal trends in mortality and readmission after acute heart failure: a systematic review and meta-regression in the past four decades. Eur J Heart Fail. 2021 Mar; 23(3): 420-431.

28．Lang, S Ishihara, et al. Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial. Eur J Heart Fail.2021 Jul;23(7): 1147-1155.

29．M Correale, S Ishihara, et a Paradigm shift in heart failure treatment: are cardiologists ready to use gliflozins? Heart Fail Rev. 2021 Jun 7. doi: 10.1007/s10741-021-10107-8.

30．N Itoh, M Maruyama, I Tsuboi, T Nohara, S Ishihara, W Shimizu. Arrhythmogenic Triggers of Atrial Fibrillation Arising from the common trunk of the inferior pulmonary veins. Circ Rep 2022; 4: 147-148.

31．M Maruyama, H Yamabe, S Takatsuki, Y Seki, S Uetake, T Nohara, I Tsuboi, S Ishihara, Y Miyauchi, W Shimizu. Last Entrainment Sequence: A Novel Diagnostic Technique for Atrial Tachycardia Mimicking Other Supraventricular Tachycardias. JACC Clin Electrophysiol. 2022 Oct; 8(10): 1289-1300.

32．M Watanabe, T Kashimura, M Ishizuka, M Kase, R Sakai, S Fujiki, T Takayama, S Ishihara, K Ozaki and T Inomata. Baseline Blood Pressure and Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy with Spontaneous Mechanical Alterans. Intern Med 2022; 9: doi: 10.2169/internalmedicine.0711-22.

33．Ishihara S, Maruyama M, Nohara T, Shimizu W, Asai K. Atrial fibrillatory wave amplitude revisited: A predictor of recurrence after catheter ablation independent of the degree of left atrial structural remodeling. Cardiol J 2023 Jan 2. doi: 10.5603/CJ.a　0120.

34．A Asakage, S Ishihara, L Boutin, F Dépret, T Sugaya, N Sato, E Gayat, A Mebazaa, B Deniau. Predictive Performance of Neutrophil Gelatinase Associated Lipocalin, Liver Type Fatty Acid Binding Protein, and Cystatin C for Acute Kidney Injury and Mortality in Severely Ill Patients. Ann Lab Med. 2023 Sep 26. doi: 10.3343/alm.2023.0083.

医療DX推進体制整備加算

当院では、医療DXを推進するための体制として、以下の項目に取り組んでいます。

①オンライン資格確認等システムにより取得した診療情報を活用して、診療を実施しています。

②マイナ保険証の利用を促進し、医療DXを通じて質の高い医療を提供できるよう取り組んでいます。

③電子処方箋の発行や、電子カルテ情報共有サービスなどの取り組みを実施してまいります。

　　（※導入準備中です）　

医療情報取得加算

当院では、以下の項目に取り組んでいます。

①オンライン資格確認を行う体制を有しています。

②受診した患者に対し、受診歴、薬剤情報、特定健診情報その他必要な診療情報・活用して診療を行っております。

一般名処方加算

現在、医薬品の供給が不安定な状況となっていることから、保険薬局において銘柄によらず調剤できるよう、一般名で処方箋を発行させていただく場合があります。

なお、令和6年10月より後発医薬品（ジェネリック医薬品）がある薬で、先発医薬品の処方を希望される場合は、特別の料金をお支払いいただいておりますのでご承知おきください。（先発医薬品を処方する医療上の必要があると認められる場合等は、特別の料金は要りません）

夜間・早朝加算

平日18：00以降・土曜日12：00以降の受付は、夜間・早朝加算（50点）の取り扱いとなりますので、ご了承ください。

指定医療機関

・生活保護法指定医療機関

・難病指定医療機関

・小児慢性特定疾病医療機関

「個別の診療報酬の算定項目の分かる明細書」の発行について

当院では、医療の透明化や患者への情報提供を積極的に推進していく観点から、領収書の発行の際に、個別の診療報酬の算定項目の分かる明細書を無料で発行しております。

明細書には使用した薬剤の名称や行われた検査の名称が記載されるものですので、ご理解いただき、明細書の発行を希望されない方は会計窓口にてお申し出ください。

緊急時の連絡先について

緊急時は順次、以下の方法にてご連絡ください。

ご不明点等ございましたら、お気軽にお問合せください。

　診療時間内

　　サンマルコクリニック　院長　南　史朗　℡　044-433-3005

　緊急（診療時間外）

　　サンマルコクリニック　院長　南　史朗　℡　044-750-0103

当院におけるかかりつけ医機能について

 当院は、発生頻度の高い疾患についての診療を行い、日常的な診療において、患者様の生活背景を把握し、適切な診 療･保健指導を行い、必要な場合には、地域の医師･医療機関と協力して解決策を提供します。この他、患者さんが適 切な医療機関の選択ができるように、当院の有する「かかりつけ医機能」に関する体制を以下のように報告します。

1.かかりつけ医機能に関する研修の修了者および総合診療専門医について
研修修了者　1名

2.一次診療の対応について

（１）一次診療の対応ができる領域

　皮膚・形成領域、神経・脳血管領域、精神科・神経科領域、呼吸器領域

　消化器系領域、肝・胆道・膵臓領域、循環器系領域、腎・泌尿器系領域

　内分泌・代謝・栄養領域、血液・免疫系領域、筋・骨格系及び外傷領域

（２）一次診療を行うことができる発生頻度が高い疾患

　貧血、糖尿病、脂質異常症、不安・ストレス（神経症）、認知症、頭痛（片頭痛）

　末梢神経障害、高血圧、狭心症、不整脈、心不全、喘息・COPD、かぜ・感冒

　アレルギー性鼻炎、下痢・胃腸炎、便秘、慢性肝炎（肝硬変、ウイルス性肝炎）

　皮膚の疾患、関節症（関節リウマチ、脱臼）、骨粗しょう症、腰痛症、慢性腎臓病

　更年期障害